Association of Apolipoprotein E Polymorphism with Cognitive Functions in Elderly

Tadjudin, Noer Saelan and Tanra, Andi Jayalangkara and Islam, Andi Asadul and As’ad, Suryani and Massi, Muh. Nasrum and Patellongi, Ilhamjaya and Prihantono, Prihantono (2018) Association of Apolipoprotein E Polymorphism with Cognitive Functions in Elderly. Indian Journal of Public Health Research & Development, 9 (12).

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Abstract

Objective: This study aims to examine the association between apolipoprotein E polymorphism (APOE) and cognitive functions test using Montreal Cognitive Assesment- Indonesian version 2012 (MoCA-Ina) in elderly. Method: A cross-sectional study of 112 elderly participants from two nursing homes in Jakarta. APOE gene polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: There are four genotypes: E2/E2 10(8.9%), E3/E3 38(33.9%), E3/E4 46(41.1%) and E4/E4 18(16.1%). The percentage of E2 allele 20(8.9%), E3 122(54.5%), E4 82(36.6%). The cognitive function test, MoCA-Ina ≥ 26: 34(40%) participants with genotype E2/E2 3(8.8%), E3/E3 7(20.6%), E3/E4 16(47.1%) and E4/E4 8(23.5%). MoCA-Ina < 26: 51(60%) 51 participants with genotype E2/E2 7(13.7%), E3/E3 14(27.5%), E3/E4 22(43.1%) and E4/E4 8(15.7%). A significant relationship between APOE gene polymorphism with MoCA-Ina-abstraction: E3/E4 vs. E3/E3 p 0.019, E4/E4 vs. E3/E3 p = 0.028, a significant relationship between APOE gene polymorphism with MoCA-Ina-language: E3/E4 vs. E2/E2 p = 0.03, E4/E4 vs. E2/E2 p 0.029, and a significant relationship between APOE gene polymorphism with naming: E3/E4 vs. E2/E2 p = 0.048. Conclusion: High percentage of APOE allele E4 may be one of the causes of high cognitive function decline. APOE gene polymorphisms associated with the decreased cognitive function; abstraction, language, and naming. Allele E4 may be a potential factor for cognitive function decline.

Item Type: Article
Subjects: Artikel
Penelitian > Fakultas Kedokteran
Divisions: Fakultas Kedokteran > Kedokteran
Depositing User: Erik Wijaya
Date Deposited: 24 Jun 2022 02:52
Last Modified: 24 Jun 2022 02:52
URI: http://repository.untar.ac.id/id/eprint/36497

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